Methyltestosterone is an example of which administration route?

• A. Sublingual
• B. Buccal
• C. Oral
• D. Topical

Answer: (B)

Methyltestosterone is designed to be taken by mouth. It’s a 17-alpha-alkylated testosterone analog, which helps it resist breakdown in the liver long enough to enter the bloodstream when swallowed. Because of this chemistry, the standard and most practical way to administer it is as an oral tablet, providing systemic effects.

The buccal or sublingual routes bypass some liver metabolism, which is useful for certain drugs with specific absorption needs, but they’re not the typical or most effective choices for methyltestosterone. Topical administration would deliver the drug through the skin, which isn’t how this medication is conventionally used systemically.

So, the best fit for methyltestosterone is the oral route due to its formulation and pharmacokinetic properties.