Physical Dependence is defined as which?

• A. Physiological need for the drug
• B. Psychological craving for the drug
• C. Tolerance to the drug
• D. Withdrawal symptoms

Answer: (A)

Physical dependence means the body has physiologically adapted to a drug to the point where stopping it causes withdrawal symptoms, so the drug is needed to feel normal. That physiological need is what defines physical dependence, which is why this option is the best fit.

Psychological craving is about wanting the drug on a mental level, not the body's physical adaptation. Tolerance refers to needing higher doses to achieve the same effect, which can accompany dependence but isn’t the definition itself. Withdrawal symptoms are what occur when the drug is stopped, signaling dependence, but they are a consequence rather than the definition.